Medically reviewed by Austin Ulrich, PharmD
Key Takeaways
- While both treat depression, Lexapro (escitalopram) is specifically FDA-approved for generalized anxiety disorder (GAD), whereas Prozac (fluoxetine) is approved for panic disorder and obsessive-compulsive disorder (OCD).
- Lexapro has a shorter half-life, which may make it a preferred option for older adults; Prozac stays in the system longer, which can be helpful if a dose is occasionally missed.
- You can save up to 85% on your prescription costs. Compare pricing and get verified discounts at over 74,000 trusted pharmacies by visiting super.com/rx.
Choosing between medications for mental health can feel overwhelming, especially when managing costs on a fixed income or navigating a high-deductible plan. Lexapro (escitalopram) and Prozac (fluoxetine) are two of the most commonly prescribed selective serotonin reuptake inhibitors (SSRIs). This guide provides some key points to understand about their differences and how to find the most affordable way to fill your prescription.
What is Lexapro (Escitalopram)?
Lexapro is an FDA-approved SSRI designed to treat major depressive disorder in adults and adolescents, as well as generalized anxiety disorder (GAD). It works by increasing the levels of serotonin—a natural chemical messenger—in the brain to help restore emotional balance.
For many people, Lexapro is considered a preferred option because it tends to have fewer drug interactions compared to older SSRIs.
Common Side Effects of Lexapro
- Nausea or diarrhea
- Drowsiness or dizziness
- Increased sweating
- Difficulty sleeping (insomnia)
- Sexual dysfunction or decreased sex drive
- Dry mouth
What is Prozac (Fluoxetine)?
Prozac was the first SSRI to gain FDA approval in the United States. It is approved to treat conditions including major depressive disorder, obsessive-compulsive disorder (OCD), panic disorder, and bulimia nervosa.
Prozac is unique because it has a very long “half-life,” meaning it stays in the body much longer than Lexapro. This can be a functional benefit for people who occasionally forget to take their daily pill, as the levels of the medication in the blood remain more stable, reducing the risk of sudden withdrawal symptoms. However, because it stays in the system longer, it may take more time for a healthcare professional to adjust your dosage or switch you to a different treatment.
Common Side Effects of Prozac
- Nausea
- Nervousness
- Changes in appetite or weight
- Vivid dreams or sleep disturbances
- Tremors or shaking
How to Save on Your Prescriptions
The retail price for brand-name mental health medications can sometimes exceed $500 for a single month’s supply. However, you do not have to pay the full sticker price.
- Switch to Generics: The generic versions, escitalopram and fluoxetine, contain the same active ingredients as their brand-name counterparts but cost a fraction of the price.
- Use a Membership Benefit: With Super+ RX, members can access discounted pricing that is often lower than a standard insurance co-pay. Save up to 85% on your prescription costs. Compare pricing and get verified discounts at over 74,000 trusted pharmacies.
- Request a 90-Day Supply: Many healthcare professionals can write a 90-day prescription. Buying in bulk often lowers the per-pill price and reduces the number of trips to the pharmacy.
Price Comparison Table: Lexapro vs. Prozac
Prices vary significantly based on your location and the pharmacy you choose. The following table illustrates the potential savings when choosing generic options and using the Super+ RX membership.
| Medicine Name | Quantity | Estimated Average Retail Price | Estimated Super+ RX Member Price |
| Escitalopram (Generic) | 30 Tablets | ~$25.00 – $45.00 | ~$3.50 – $20.00 |
| Lexapro (Brand) | 30 Tablets | ~$880.00 – $1,000.00 | ~$470.00 – $495.00 |
| Fluoxetine (Generic) | 30 Capsules | ~$6.00 – $45.00 | ~$3.00 – $20.00 |
| Prozac (Brand) | 30 Capsules | ~$770.00 – $810.00 | ~$415.00 – $440.00 |
Note: Prices are estimates based on 2026 data and common 10mg or 20mg dosages. Prices are subject to change.
FAQ: Common Questions About Lexapro and Prozac
Which is better for anxiety?
Lexapro is specifically FDA-approved for GAD. While Prozac is approved for panic disorder and OCD, a healthcare professional may prescribe either based on your specific symptoms and diagnosis.
Can I switch from Prozac to Lexapro?
Yes, but it must be done under the guidance of a healthcare professional. Because Prozac stays in your system for several weeks, the “washout” period or transition timing is different than with other medications.
Will I gain weight on these medications?
Weight changes are possible with any SSRI. Studies show that weight gain may be slightly more common with Lexapro, while Prozac is sometimes associated with initial weight loss or appetite reduction in the short term.
Does Lexapro work faster than Prozac?
Some clinical data suggest Lexapro may begin reducing symptoms within 1 to 2 weeks for some people, whereas Prozac typically takes 2 to 4 weeks to reach therapeutic levels. However, everyone responds differently, and all SSRIs typically take a few weeks of consistent use before noticeable improvement.
Are these covered by Medicare?
Most Medicare Part D plans cover the generic versions (escitalopram and fluoxetine). If you find yourself in a gap in coverage where your out-of-pocket costs rise, using the Super+ RX coupon may provide a lower price than your plan’s co-pay.
Your Savings Roadmap
To start saving today, visit super.com/rx to search for your specific dosage and compare prices at pharmacies in your neighborhood. Simply show the digital Super+ RX discount coupon to your pharmacist when you drop off your prescription to apply your member savings immediately.
Save on your prescription: Visit Super.com/rx to compare prices at 74,000+ pharmacies and use your digital coupon for immediate savings.
References
Landy K, Rosani A, Estevez R. Escitalopram. StatPearls. November 10, 2023. Accessed April 16, 2026. https://www.ncbi.nlm.nih.gov/books/NBK557734/
Leonard B, Taylor D. Escitalopram–translating molecular properties into clinical benefit: reviewing the evidence in major depression. J Psychopharmacol. 2010;24(8):1143-1152. doi:10.1177/0269881109349835
Sohel AJ, Shutter MC, Patel P, Molla M. Fluoxetine. StatPearls. February 28, 2024. Accessed April 16, 2026. https://www.ncbi.nlm.nih.gov/books/NBK459223/
Disclaimer:
Generative AI was used in the development of this content. All information in this article has been reviewed by our highly-trained clinicians. We do not provide medical advice. Please, consult a physician.
