Medically reviewed by Austin Ulrich, PharmD
Key Takeaways
- Medications like atorvastatin (Lipitor) and rosuvastatin (Crestor) are the most commonly prescribed to lower low-density lipoprotein (LDL) cholesterol, often referred to as bad” cholesterol.
- Most common cholesterol medications have generic versions that provide the same clinical benefits at a fraction of the retail price.
- You can save up to 85% on your prescription costs by comparing prices and using a Super+ RX discount coupon.
Managing high cholesterol is a long-term commitment. For many Americans, especially those who are uninsured or managing multiple chronic (long-term) conditions, the cost of monthly prescriptions can be a significant burden. This guide breaks down the most common cholesterol-lowering medications and explains how you can reduce your out-of-pocket expenses.
What are Statins?
Statins are a class of medications that work by blocking an enzyme in the liver that your body needs to produce cholesterol. By reducing the amount of cholesterol in your blood, these medications help prevent the buildup of plaque in your arteries, which reduces the risk of heart attack and stroke.
Atorvastatin (Lipitor)
Atorvastatin is one of the most widely prescribed cholesterol medications in the United States. Higher doses of atorvastatin are considered to be high-intensity statin therapy, meaning this medication is very effective at lowering LDL cholesterol. It is often a first choice for individuals who need significant cholesterol reduction.
- Common Dosages: 10 mg, 20 mg, 40 mg, 80 mg.
- Side Effects: Muscle aches, digestive upset, and mild increases in blood sugar levels.
Rosuvastatin (Crestor)
Rosuvastatin is another potent statin used to lower “bad” cholesterol and triglycerides while slightly increasing “good” HDL cholesterol. It is frequently prescribed for people who may not have reached their target levels on other medications.
- Common Dosages: 5 mg, 10 mg, 20 mg, 40 mg.
- Side Effects: Headache, muscle pain, abdominal pain, and weakness.
Simvastatin (Zocor)
Simvastatin is a moderate-intensity statin that has been used for decades. It is a reliable option for those who need to lower their cholesterol but may not require the high-intensity impact of newer statins.
- Common Dosages: 10 mg, 20 mg, 40 mg.
- Side Effects: Upper respiratory infections, headache, and muscle pain.
Pravastatin
Pravastatin is often considered a “gentler” statin. It is less likely to interact with other medications and may have a lower risk of muscle-related side effects, making it a possible choice for older adults or those on multiple prescriptions.
- Common Dosages: 10 mg, 20 mg, 40 mg, 80 mg.
- Side Effects: Nausea, vomiting, and muscle pain.
What are Cholesterol Absorption Inhibitors?
Unlike statins, which stop cholesterol production in the liver, these medications prevent your body from absorbing cholesterol from the food you eat.
Ezetimibe (Zetia)
Ezetimibe is a common non-statin cholesterol medication. It can be used alone for those who cannot tolerate statins or in combination with a statin to further lower LDL levels.
- Common Dosages: 10 mg.
- Side Effects: Fatigue, diarrhea, and joint pain.
How to Save on Your Cholesterol Medication
The price of these essential medications can vary depending on which pharmacy you visit and whether you choose the brand name or the generic version.
| Medication | Average Retail Price (Approx.) | Super+ RX Member Price |
| Atorvastatin (Generic) Lipitor (Brand) | ~$25.00 – $45.00 ~$310.00 – $790.00 | ~$4.00 – $19.00 ~$175.00 – $430.00 |
| Rosuvastatin (Generic) Crestor (Brand) | ~$25.00 – $45.00 ~$190.00 – $620.00 | ~$4.00 – $19.00 ~$170.00 – $280.00 |
| Simvastatin (Generic) Zocor (Brand) | ~$15.00 – $40.00 ~$250.00 – $350.00 | ~$3.00 – $20.00 ~$125.00 – $170.00 |
| Ezetimibe (Generic) Zetia (Brand) | ~$45.00 – $75.00 ~$1,250.00 – $2,500.00 | ~$15.00 – $30.00 ~$710.00 – $1,360.00 |
Step-by-Step Savings Roadmap
- Search and Compare: Visit super.com/rx to search for your specific medication and dosage. Compare prices at over 74,000 trusted pharmacies near you.
- Choose Generic: Ask your healthcare professional if a generic version is appropriate for you. Generics are FDA-approved to be just as safe and effective as brand-name medications but cost significantly less.
- Get Your Coupon: Once you find the best price, download or print your Super+ RX digital discount coupon.
- Show and Save: Present the coupon to your pharmacist when you drop off your prescription. The discount is applied immediately.
Frequently Asked Questions
What is the generic version of Lipitor?
The generic version of Lipitor is atorvastatin. It contains the same active ingredient and provides the same cholesterol-lowering benefits at a much lower cost.
Can I use a Super+ RX coupon if I have insurance?
Yes. If you have a high-deductible plan or if your insurance does not cover a specific medication, the Super+ RX price may actually be lower than your typical co-pay. Simply ask the pharmacist to run the coupon instead of your insurance.
Why does the price of my medication change at different pharmacies?
Pharmacies set their own retail prices based on their contracts with suppliers. By using our comparison tool (Super.com.rx), you can see these price differences in real-time and choose the most affordable location.
Are generic cholesterol drugs as safe as brand names?
Yes. The FDA requires generic medications to have the same quality, strength, and purity as brand-name products. They work the same way in the body and provide the same clinical benefits.
What should I do if I can’t afford my monthly refill?
We recommend checking Super.com/rx before every refill. Prices can change, and a new discount may be available at a nearby pharmacy that makes your medication more affordable.
Save up to 85% on your prescription costs. Compare pricing and get verified discounts at over 74,000 trusted pharmacies with Super.com.rx.
References
ClinCalc. Atorvastatin. ClinCalc DrugStats Database version 2025.08. Accessed March 19, 2026. https://clincalc.com/DrugStats/Drugs/Atorvastatin
Sizar O, Nassereddin A, Talati R. Ezetimibe. StatPearls. August 28, 2023. Accessed March 19, 2026. https://www.ncbi.nlm.nih.gov/books/NBK532879/
Sizar O, Khare S, Patel P, Talati R. Statin medications. StatPearls. February 29, 2024. Accessed March 19, 2026. https://www.ncbi.nlm.nih.gov/books/NBK430940/
Disclaimer:
Generative AI was used in the development of this content. All information in this article has been reviewed by our highly-trained clinicians. We do not provide medical advice. Please, consult a physician.
